basic FUNCTION
| playing an important role during development in segmentation, where it is required for the formation of posterior compartments |
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involved in the normal cerebellar development |
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may also have a role in cell-cell communication |
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may participate directly in topographic map formation in the vertebrate visual system |
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involved in transcriptional and translational modulation |
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seems to be capable of acting as a morphogen in its own right |
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its expression is required for the maintenance of the transformed phenotype of a breast tumor cell line |
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transcriptional repressor, but, its secreted form can also promote local protein synthesis in the growth cones by regulating EIF4E-dependent translation initiation |
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regulates genes related to vesicle formation and transport in cerebellar Purkinje cells |
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EN1, EN2 represent a new class of genes that are fundamental to patterning cerebellum foliation throughout the mediolateral axis and that act late in development |
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EN1, EN2 are required for patterning the morphological and molecular domains along both axes, as well as for the establishment of the normal afferent topography required to generate a fully functional cerebellum |
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EN1 and EN2 have overlapping functions in the cells derived from each progenitor zone in regulating formation of additional fissures and for extensive cerebellar growth |
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EN1 but not EN2 has a direct and specific repulsive effect on motor axons of the lateral aspect of the lateral motor column (LMC) but not on medial LMC projections |
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plays an important role in the regionalization of the neural tube |