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FLASH GENE
Symbol ANXA7 contributors: mct - updated : 29-08-2023
HGNC name annexin A7
HGNC id 545
Location 10q22.2      Physical location : 75.135.188 - 75.173.841
Synonym name
  • lipocortin VII (synexin)
  • annexin VII
  • Synonym symbol(s) LPC7, ANX7, SNX, ANX7, SYNEXIN
    DNA
    TYPE functioning gene
    STRUCTURE 38.96 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing polyA site 2443 50.3 466 - 2019 31446642
  • ANXA7A
  • 14 splicing polyA site 2509 51 488 brain, cardiac, skeletal muscle 2019 31446642
  • ANXA7B
  • insertion of an exon cassette
  • 12 - 2388 - 426 - 2019 31446642
    13 - 2454 - 448 - 2019 31446642
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrineadrenal glandmedulla   
     neuroendocrinepituitary  highly
     parathyroid   highly
     thyroid   highly
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousautonomous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a long hydrophobic 167 AA N terminus
  • a C terminal "core" region
  • four repeats homolog to the endonexin fold
  • HOMOLOGY
    interspecies homolog to murine Anxa7
    homolog to C.elegans T07C4.9
    Homologene
    FAMILY
  • annexin family of calcium-dependent phospholipid binding protein
  • CATEGORY tumor suppressor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text stomatin, sorcin, and synexin were shown to locate mainly outside induced GM1 (ganglioside M1) patches in the human erythrocyte membrane
    basic FUNCTION
  • promoting membrane fusion
  • membrane binding protein with voltage-sensitive calcium channel activity, ion selectivity and membrane fusion
  • mediating galectin-3 (LGALS3) translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation
  • ANXA7 and sorcin are cytosolic proteins that are actors in vesicular trafficking and exocytosis
  • ANXA7 is an important factor in tumors with the lymphatic metastasis
  • calcium-dependent phospholipid-binding protein
  • ANXA7 has a conserved role in regulating endometrial receptivity and implantation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text voltage dependent calcium channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • protein
  • interacting with LGALS3
  • ANXA7 is an interaction protein of TIA1
  • cell & other membrane
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in prostate cancer especially metastatic
    tumoral   LOH    
    in hormone receptor negative breast carcinomas with poor prognosis
    constitutional     --low  
    significantly lower in placentas from patients with Preeclampsia (PE) patients compared with that in from normal pregnant controls
    constitutional     --low  
    decreased during the midluteal window of implantation in women suffering from recurrent pregnancy loss (RPL) when compared to subfertile patients
    tumoral     --low  
    might suppress the proliferation and metastasis of human hepatocellular carcinoma cells via MAPK/ ERK pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductionpregnancy 
    is a potential therapeutic target for preeclampsia
    cancerdigestiveliver
    ANXA7-LEPR is a promising therapeutic target for liver cancer treatments
    cancerdigestivestomach
    effect of annexin A7 suppression on the apoptosis of gastric cancer cells
    ANIMAL & CELL MODELS
    Anxa 7 -/- mice (Herr, 2001)