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FLASH GENE
Symbol C8G contributors: mct - updated : 11-01-2012
HGNC name complement component 8, gamma polypeptide
HGNC id 1354
Location 9q34.3      Physical location : 139.839.697 - 139.841.426
Genatlas name complement component 8,gamma-1 globulin,subunit of the membrane attack complex
Synonym symbol(s) C8C, MGC142186
DNA
TYPE functioning gene
STRUCTURE 1.73 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 888 - 202 - 2007 17452033
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 stomach    
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a beta-barrel fold that forms a binding pocket for a small, generally hydrophobic ligand
  • secondary structure comprising a single eight-stranded continuously hydrogen-bounded antiparallel beta-barrel which encloses an internal ligand binding site
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine C8g
    Homologene
    FAMILY lipocalin family (kernel group) of small secreted protein
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • C8 gamma is not required for complement-mediated killing of Gram-negative bacteria
  • one of five complement components (C5b, C6, C7, C8, and C9) that assemble on bacterial membranes to form a porelike structure referred to as the "membrane attack complex" (MAC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • C8 is composed of three genetically distinct subunits, C8A, C8B, and C8G
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by CD59
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS