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FLASH GENE
Symbol PNLIP contributors: mct - updated : 09-05-2011
HGNC name pancreatic lipase
HGNC id 9155
Location 10q25.3      Physical location : 118.305.427 - 118.327.366
Synonym name
  • pancreatic triacylglycerol lipase
  • triacylglycerol acylhydrolase
  • pancreatic triglyceride lipase
  • Synonym symbol(s) PL, PTL, RP11-33D13.1, PNLIPD
    EC.number 3.1.1.3/ 3.1.1.21
    DNA
    TYPE functioning gene
    STRUCTURE 21.94 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1502 - 465 - 2005 16179352
    EXPRESSION
    Rna function mRNA is not expressed in the fetal pancreas or at birth
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas   highly
    Lymphoid/Immunelymph node    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain belongs to the alpha/beta hydrolase fold and contains the active site, which involves a catalytic triad analogous to that present in serine proteases
  • a PLAT domain
  • beta-sandwich C-terminal domain playing an important part in the binding process between the lipase and colipase, the specific PNLIP cofactor, and having structural homologies with the C2 domains occurring in a wide range of proteins involved in signal transduction
  • HOMOLOGY
    Homologene
    FAMILY AB hydrolase superfamily, lipase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • encoding a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats
  • PNLIP and CEL serve complementary functions, working together to mediate the absorption of a major portion of dietary fat and fat-soluble vitamin esters
  • plays very important roles in the digestion and absorption of lipids
  • may potentially be involved in the pathophysiology of traumatic brain injury and may be implicated in the proliferation of astrocytes and the recovery of neurological outcomes
  • predominant lipase secreted by the exocrine pancreas
  • its activity is restored by the addition of another pancreatic protein, colipase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    inhibitors of pancreatic lipase are new players in obesity treatment
    ANIMAL & CELL MODELS
  • delayed fat digestion due to Pnlip deficiency results in a significant reduction in cholesterol absorption, although other enzymes in the digestive tract may compensate for the lack of Pnlip in PTnlip -/-mice in fat digestion and absorption