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FLASH GENE
Symbol TRDMT1 contributors: mct/pgu - updated : 21-03-2011
HGNC name tRNA aspartic acid methyltransferase 1
HGNC id 2977
Location 10p15.1      Physical location : 17.184.982 - 17.244.070
Synonym name
  • DNA (cytosine-5-)-methyltransferase 2
  • DNA methyltransferase homolog HsaIIP
  • Synonym symbol(s) DNMT2, RNMT1, DNA, PuMet
    EC.number 2.1.1.37
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 54.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 7687 - 391 - 2001 11139614
    - - 3467 - 367 - 2003 12794065
    - - 3401 - 345 - 2003 12794065
    - - 3396 - 63 - 2003 12794065
    - - 3290 - 71 - 2003 12794065
    - - 3324 - 117 - 2003 12794065
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Reproductivefemale systembreastmammary gland  
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic cytosine-5 DNA methyltransferase gene family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • DNA methyltransferase, 2 (5-methyl-cytosine), not essential for global de novo or maintenance methylation in embryonic stem (ES) cells
  • having residual DNA-(cytosine-C5) methyltransferase activity
  • methylating tRNA(Asp)
  • methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to spina bifida
    Variant & Polymorphism other significant associations with spina bifida
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS