Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CPB1 contributors: mct - updated : 19-03-2008
HGNC name carboxypeptidase B1 (tissue)
HGNC id 2299
Location 3q24      Physical location : 148.545.587 - 148.577.970
Genatlas name pancreas specific protein
Synonym name
  • carboxypeptidase B, pancreatic
  • pancreatic carboxypeptidase B1
  • Synonym symbol(s) PCYB, PASP, PCPB
    EC.number 3.4.17.2
    DNA
    TYPE functioning gene
    STRUCTURE 32.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1473 - 417 - Guimaraes (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas   highly Homo sapiens
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion secreted in serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 15AA signal/leader peptide
  • a 94-96-amino acid-long propeptide
  • a catalytic moiety with a zinc binding domain
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to C.elegans y59c2a.1
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulate the plasminogen system both in the matrix and on the cell surface, thus leading to the inhibition of endothelial cell movement and tube formation
  • cleave off basic C-terminal residues and secreted as inactive zymogens
  • CPB1 hydrolyzes C-terminal lysine and arginine residues generated by tryptic cleavages
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene serum marker for acute pancreatitis
    Marker
    Therapy target
    ANIMAL & CELL MODELS