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FLASH GENE
Symbol LY6E contributors: - updated : 24-02-2004
HGNC name lymphocyte antigen 6 complex, locus E
HGNC id 6727
Location 8q24.3      Physical location : 144.099.901 - 144.103.827
Genatlas name thymic shared antigen 1
Synonym name retinoic (all-trans,ATRA) acid induced gene E
Synonym symbol(s) RIGE,TSA1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 3.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveliver   highly
Endocrinepancreas   highly
Reproductivefemale systemovary   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Blood/Hematopoieticthymocyte
cell lineage
cell lines tumor cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GPI-anchored receptor protein with ten conserved cysteine residues,N terminus (signal peptide) and an extracellular sequence of 111AA.
  • .one UPAR/LY6 domain
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ly6e
    intraspecies homolog to CD59
    Homologene
    FAMILY
    CATEGORY antigen , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached by a Gpi-anchor
    basic FUNCTION cell surface receptor linked signal transduction involved in defense responses
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component constituent of lymphocyte antigen 6 complex
    s2 glycosylphosphatidylinositol (GPI)-anchored constituent of cell surface membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by retinoic acid during the differentiation of acute promyelocytic leukemia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS