basic FUNCTION
| negative regulator of T-cell receptor signaling |
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functions in a pathway that requires the phosphorylated CD247 and the Src family kinase LCK, but not ZAP70 (zeta-associated protein of 70 kD) |
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SLA and CBL recently have been shown to cooperate in regulating T cell receptor (TCR) levels in developing T cells |
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has a conserved function in B and T cells by adapting CBL to the antigen-receptor complex and targeting it for degradation |
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inhibitor of T- and B-cell receptor signaling |
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negatively regulates differentiation of osteoclasts and proliferation of their precursors |
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SLA and SLA2-mediated CSF2RA regulation is important for the generation of functionally mature monocytic dendritic cells |