protein
| phosphorylating HTATSF1 (hSpt5) for interaction with PIN1 |
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CCNT (PTEFB activation involved in cardiac muscle-cell hypertrophy) |
|
RB protein |
|
CCNT1 |
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interacting with HIV Tat, suggesting a possible involvement in AIDS |
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CDK9 and CCNK interact with ataxia telangiectasia and Rad3-related protein and other checkpoint signalling proteins |
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CDK9 binds to cyclin K and direct role of CDK9-CCNK in pathways that maintain genome integrity in response to replication stress appear to be evolutionarily conserved |
|
AIRE requires CDK9 to activate transcription elongation and co-transcriptional processing of target genes |
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TAF7 interacts with and regulates the enzymatic activities of other transcription factors, including CDK9, GTF2H1, and CIITA, ensuring an orderly progression in transcription initiation |
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CDK9 the kinase of CCNT1 stimulates transcription elongation by phosphorylating POLR2A and transcription elongation factors |
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CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation |
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BCL11B is a major modulator of CDK9 activity, and controls CDK9 function in physiological and pathological conditions |
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interactions of both JMJD6 and BRD4 with the CDK9 complex permit its activation and pause release of regulated coding genes |
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CDK9 is required for the transition from initiation to elongation of transcription, and its AIRE interaction ensures proper expression of AIRE-responsive tissue-specific antigens in the thymus |
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HEXIM1 binds to the CDK9 catalytic site to inhibit CCNT1 |