basic FUNCTION
| important regulator of vertebrate limb myogenesis, and of vascular differentiation |
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involved in regulating epithelial-mesenchymal cell interactions in extraembryonic tissues |
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activates CDKN1A through multiple upstream AT-rich sequences |
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regulate endothelial cell proliferation and muscle development |
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primarily involved in the TGF-beta tumor suppressor pathway |
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with SOSTDC1, may have a role in the progression of Wilms tumorigenesis |
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homeoprotein which inhibits nuclear factor-kappaB (NF-kappaB) signalling and endothelial cells activation in response to serum and proangiogenic factors |
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modulates the activity of the RELA complex through direct interaction with its components |
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an important regulator of vascular cell proliferation and is a direct transcriptional activator of both CDKN1A and CDKN2A |
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MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes |