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FLASH GENE
Symbol RPA3 contributors: mct/pgu - updated : 05-03-2012
HGNC name replication protein A3, 14kDa
HGNC id 10291
Location 7p22      Physical location : 7.676.576 - 7.758.238
Genatlas name G replication protein A, subunit 3
Synonym name
  • RF-A protein 3
  • RP-A p14
  • replication protein A 14 kDa subunit
  • Synonym symbol(s) REPA3, RPA14
    DNA
    TYPE functioning gene
    STRUCTURE 81.66 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1613 13.4 121 - 2009 19010961
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
     brain    
     braindiencephalonhypothalamus  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to yeast Rfa3
    ortholog to Schizosaccharomyces pombe Ssb3
    Homologene
    FAMILY replication protein A family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in DNA replication, repair, and recombination
  • with RPA1, and RPA2, plays essential roles in DNA transactions
  • single-stranded (ss) DNA-binding protein highly conserved in eukaryotes and playing essential roles in many aspects of nucleic acid metabolism, including replication, recombination, DNA repair and telomere maintenance
  • playing potentially a critical role in mediating RPA functions that are required for repair or tolerance of DNA lesions in S-phase
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair, nucleotide excision repair
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a trimeric single strand binding protein,the replication protein A complex,involved in replication,homologous recombination and nucleotide excision repair
  • INTERACTION
    DNA interacting directly with ssDNA
    RNA
    small molecule
    protein
  • interacts with the specific proteins among those that play roles in the regulation of the replication fork progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS