protein
| flavoprotein P450 oxidoreductase (POR) |
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NR5A2 is a key transcriptional factor required for the hepatic expression of CYP7A1 |
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PPARGC1A is necessary for fasting-mediated induction of CYP7A1 |
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NR5A2 controls CYP7A1 expression from two distinct sites, i.e., liver and ileum, in the enterohepatic circulation |
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FGF7 inhibited CYP7A1 gene expression in hepatocytes and suppression of CYP7A1 expression by FGF7 was mediated by FGFR2 and its downstream JNK signaling cascade |
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thyroid hormone regulated step involves induction of CYP7A1, which enhances cholesterol to bile acid conversion and plays a crucial role in regulation of serum cholesterol levels |
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NR2F2 variant 2 negatively regulates the function of NR2F2 by inhibiting its binding to DNA to decrease CYP7A1 expression |
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PROX1 interacts with KDM1A to recruit the repressive KDM1A/NuRD complex to CYP7A1 promoter and co-represses transcription through epigenetic mechanisms |
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activation of the VDR represses hepatic NR0B2 to increase levels on CYP7A1 and reduce cholesterol |