SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton
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| intracellular,nucleus,nucleolus
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text
| is a nucleocytoplasmic shuttling protein which is actively imported into and exported out of the nucleus |
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INPP5D nuclear puncta partially colocalize with CASP8AP2, a component of nuclear bodies |
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also colocalizes in nucleolar cavities with components of the ubiquitin-proteasome pathway |
basic FUNCTION
| acting as a negative regulator of lymphocyte activation and of myeliod cell proliferation and survival |
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inhibiting ras signaling by competing with GRB2 |
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down-regulating cytokine receptor signaling in myeloid cells |
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acts by hydrolysing the 5-phosphates from PtdIns(3,4,5)P(3) and Ins(1,3,4,5)P(4), thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathway (Gloire 2007) |
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not only acts as a negative player in T-cell lines proliferation, but also regulates critical pathways, such as NF-kappaB (nuclear factor kappaB) activation, and also appears to remarkably inhibit T-cell apoptosis (Gloire 2007) |
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plays a major role in inhibiting proliferation of myeloid cells |
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involved in the signal terminating reaction in the inositol signaling pathway |
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playing a major role in controlling PtdIns(3,4,5) P3 levels in response to thrombin or collagen activation |
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with INPP5E and INPP5K, implicated in negatively regulating insulin signalling and glucose homoeostasis in specific tissues (Ooms 2009) |
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regulate macrophage phagocytosis, and also controls haemopoietic cell proliferation (Ooms 2009) |
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its inactivation could play a central role in the deregulation of Akt pathway and tumorigenesis, perhaps in conjunction with PTEN inactivation (Lo 2009) |
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cannot bind to ubiquitin, which is consistent with the fact that does not contain such a UIM domain (De Schutter 2009) |
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negative regulator of signaling processes in hematopoietic cells |
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plays likely a role for nuclear phosphoinositide and/or nuclear inositol phosphate signaling |
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INPP5D, DOK1 and DOK2 play central roles in CD4-mediated inhibitory signaling |
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its presence at focal adhesions and lamellipodia could suggest a role in cell adhesion and migration |
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is an adhesion molecule that control NK cell cytotoxicity and interferon-gamma production against a wide range of cancer and infected cells |
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INPP5D control of natural killer cells functions through nectin and nectin-like proteins |