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FLASH GENE
Symbol CD180 contributors: mct - updated : 03-04-2020
HGNC name CD180 antigen
HGNC id 6726
Location 5q12.3      Physical location : 66.478.103 - 66.492.617
Synonym name
  • lymphocyte antigen 64 homolog, radioprotective 105kDa
  • radioprotective 105kDa
  • Synonym symbol(s) RP105, Ly78, LY64, MGC126233, MGC126234
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 17.19 kb     3 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 5388 - 661 - 2017 29284783
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen    
     tonsils    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 17 LRR repeats
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer complex
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to lymphocyte antigen 64 (murine)
    intraspecies homolog to TLR4
    Homologene
    FAMILY toll-like receptor family
    CATEGORY regulatory , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • implicated in the life/death (apoptosis) decision of B cell
  • involved in signaling of LPS and innate immune response
  • leading to NK-kappa B activation
  • contributes in a unique way to the TLR4-dependent survival, proliferation and plasma cell generation of Marginal zone (MZ) B cells
  • playing a role in regulation of B cell growth and death
  • inhibitor of TLR4 by inhibiting its ability to bind microbial ligand
  • CD180-negative B cells, which are dramatically increased in systemic lupus erythematosus (SLE) patients, are responsible for the production of auto-antibodies
  • protects liely the myocardium against apoptosis and autophagy, and plays a cardioprotective role during I/R injury
  • SLAMF1 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells (
  • ameliorates hypoxia&
  • 824;reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4&
    824;MAPKs&
    824;NFKB1 signaling
  • CD180, a TLR-like protein, is specifically involved in the development and activation of immune cell
  • CD180, a TLR-like protein, can regulate the proliferation and activation of immune cells
  • ligation of CD180 contributes to the pathogenesis of endotoxic shock by inhibiting the accumulation and immunosuppressive activity of granulocytic Myeloid-derived suppressor cells (MDSCs), thus providing insight into the function of CD180 in inflammatory diseases
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    text innate immunity
    PATHWAY
    metabolism
    signaling
    a component complexed with LY86
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding TLR4
  • potentiation of TLR9 responses for human na
  • ve B-cell growth through CD180 signaling
  • CD180 stimulation induces intrinsic B cell proliferation and differentiation, causing rapid increases in IgG, and integrates MyD88-dependent TLR signals to regulate proliferation, cytokine production, and differentiation
  • not only TLR4 signaling, but also CD180 appears to be an essential accessory for immune responses through TLR2 signaling
  • close association between the increased proportion of CD180-negative B cells and the activation of IFNA1 signaling in SLE
  • implicated in the pathological process of multiple cardiovascular diseases through its functional and physical interactions with Toll&
  • 8209;like receptor 4 (TLR4)
  • critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and Dendritics cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased expression in systemic lupus erythematosus (SLE)
    constitutional       gain of function
    in children with Kawasaki disease or viral infections (higher than in those with bacterial infections or in healthy controls)
    constitutional       loss of function
    results in reduced early atherosclerotic plaque development with a marked decrease in lesional macrophage content, which may be due to disturbed migration of RP105 deficient monocytes resulting from CCR2 downregulation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    can be regarded as a potential therapeutic target for SLE treatment
    cardiovascularatheroma 
    may represent an innovative therapeutic target for attenuating myocardial ischemia/reperfusion (I/R) injury (MIRI)
    ANIMAL & CELL MODELS