basic FUNCTION
| implicated in the life/death (apoptosis) decision of B cell |
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involved in signaling of LPS and innate immune response |
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leading to NK-kappa B activation |
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contributes in a unique way to the TLR4-dependent survival, proliferation and plasma cell generation of Marginal zone (MZ) B cells |
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playing a role in regulation of B cell growth and death |
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inhibitor of TLR4 by inhibiting its ability to bind microbial ligand |
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CD180-negative B cells, which are dramatically increased in systemic lupus erythematosus (SLE) patients, are responsible for the production of auto-antibodies |
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protects liely the myocardium against apoptosis and autophagy, and plays a cardioprotective role during I/R injury |
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SLAMF1 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells ( |
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ameliorates hypoxia& |
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824;reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4& |
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824;MAPKs& |
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824;NFKB1 signaling |
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CD180, a TLR-like protein, is specifically involved in the development and activation of immune cell |
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CD180, a TLR-like protein, can regulate the proliferation and activation of immune cells |
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ligation of CD180 contributes to the pathogenesis of endotoxic shock by inhibiting the accumulation and immunosuppressive activity of granulocytic Myeloid-derived suppressor cells (MDSCs), thus providing insight into the function of CD180 in inflammatory diseases |