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FLASH GENE
Symbol ARSB contributors: mct/npt - updated : 28-08-2009
HGNC name arylsulfatase B
HGNC id 714
Corresponding disease
MPS6 mucopolysaccharidosis, type VI
Location 5q14.1      Physical location : 78.073.038 - 78.282.357
Synonym name N-acetylgalactosamine-4-sulfate sulfatase
Synonym symbol(s) ASB, G4S
EC.number 3.1.6.12
DNA
TYPE functioning gene
STRUCTURE 209.32 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 6076 59 533 - Petry, Bhattacharyya (2008)
8 - 2172 - 413 - Petry, Bhattacharyya (2008)
has an alternate 3' sequence
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node    
 spleen   highly
Reproductivefemale systembreastmammary gland highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal 43kDa
  • two C ter fragments 78kDa, linked by disulfide bonds
  • mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Arsb
    Homologene
    FAMILY
  • sulfatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    text with ARSA exist on the cell surface of sinusoidal endothelial cells, hepatocytes, and sinusoidal macrophages (Kupffer cells), as well as in the lysosome (Mitsunaga-Nakatsubo 2009)
    basic FUNCTION
  • removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-sulfate (C4S) (Bhattacharyya 2009)
  • having potential vital role, due to its impact on chondroitin sulfation, on determination of the invasive phenotype of colonic epithelial cells (Bhattacharyya 2009)
  • acting on dermatan sulfate
  • catalyzing the third step of degradation of glucosaminoglycans (mucopolysaccharides)
  • involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulation of CHST11 expression by opposing effects of arylsulfatase B on BMP4 and WNT9A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MPS6
    related resource Mucopolysaccharidosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    rat MPS-VI model, feline, murine