Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ARG1 | contributors: shn/npt - updated : 10-05-2009 |
HGNC name | arginase, liver |
HGNC id | 663 |
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Corresponding disease |
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Location | 6q23.2 Physical location : 131.894.364 - 131.905.468 | ||
Synonym name | |||
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Synonym symbol(s) | A-I | ||
EC.number | 3.5.3.1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 11.10 kb 8 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | Y | status | provisional |
Map | by a combination of somatic cell hybrid analysis and in situ hybridization the human liver arginase gene was mapped to 6q23 cen - D6S262 - D6S457 - ARG1- D6S1656 - D6S472 - qter |
Authors | Sparkes (1986) |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
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cells |
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cell lineage
cell lines
| fluid/secretion
| blood | |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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mono polymer | homomer , trimer |
HOMOLOGY |
interspecies | ortholog to Arg1, Rattus norvegicus |
ortholog to Arg1, Mus musculus |
Homologene |
FAMILY |
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm,cytosolic |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism | aminoacid |
signaling |
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a component |
INTERACTION |
DNA |
RNA |
small molecule | metal binding, cofactor, |
protein | |
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cell & other |
REGULATION |
activated by | Gcn4p |
induced by | arginine | |
homoarginine |
repressed by | Mcm1p |
ASSOCIATED DISORDERS |
corresponding disease(s) | ARG1 |
Susceptibility | to myocardial infarction and common carotid intima media thickness. |
Variant & Polymorphism other | Polymorphisms increasing the risk of myocardial infarction and common carotid intima media thickness. |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
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