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FLASH GENE

Symbol

PSMB9

contributors: mct - updated : 22-08-2014

HGNC name	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2)
HGNC id	9546

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.3      Physical location : 4.054.044 - 32.827.626
Synonym name	low molecular mass polypeptide 2
	proteasome subunit beta-1i
	proteasome subunit beta 6i
	multicatalytic endopeptidase complex chain 7
	really interesting new gene 12 protein
Synonym symbol(s)	LMP2, MPC2, RING12, beta1i, PSMB6i, MGC70470
EC.number	3.4.25.1

DNA

TYPE	functioning gene
STRUCTURE	5.69 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

located in the class II region of the MHC

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002800 6 splicing 1048 NP_002791 23.3 219 - 1992 1429565 also called LMP2.L

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive liver         Endocrine pancreas         Nervous brain         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Psmb9
	homolog to C.elegans pbs-1

Homologene

FAMILY

peptidase T1B family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways
	involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
	unexpected role for the immunoproteasome subunit PSMB9 in antiviral humoral and innate immune responses
	subunit of the immunoproteasome that is overexpressed in oncocytic lesions of the thyroid gland

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

immunity/defense

text	anti-pathogen response

PATHWAY

metabolism

signaling

a component

component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

IFNG directly controls IL33 protein level through a STAT1- and PSMB9-dependent mechanism

cell & other

REGULATION

induced by

gamma interferon

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive uterus role of PSMB9 as a tumor suppressor may lead to new therapeutic targets in human uterine leiomyosarcoma

ANIMAL & CELL MODELS