basic FUNCTION
| mediating cell to cell and cell to matrix interactions |
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intervertebral disc extracellular matrix (ECM) proteins that regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling |
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play a biologically significant role in tumor vascularization in Ewing's sarcoma (EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins) |
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its diverse functions may also include a role as an intermediary protein that facilitates transcellular receptor-ligand interactions |
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its expression in the heart protects against age-dependent dilated cardiomyopathy |
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enhances Notch signaling and binds to both JAG1 and NOTCH3 ectodomains, potentially bridging two essential extracellular components of NOTCH signaling |
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astrocyte-derived thrombospondin-2 is critical for the repair of the blood-brain barrier |
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highly conserved matricellular protein regulating inflammation, angiogenesis and extracellular matrix remodeling |
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matricellular protein that have been shown to regulate cytoskeleton, cell adhesion, and extracellular matrix remodeling |