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FLASH GENE
Symbol DPEP1 contributors: mct - updated : 28-03-2019
HGNC name dipeptidase 1 (renal)
HGNC id 3002
Location 16q24.3      Physical location : 89.679.715 - 89.704.838
Synonym symbol(s) RDP, MDP, MBD1
EC.number 3.4.13.19
DNA
TYPE functioning gene
STRUCTURE 28.23 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1664 - 411 - 2002 12144777
11 - 1752 - 411 - 2002 12144777
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Hearing/Equilibriumear   predominantly Homo sapiens
Respiratorylung     Homo sapiens
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion sreum, urine
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal signal peptide, a 22-amino acid signal peptide
  • four potential N-glycosylation sites
  • a GPI-acnhor
  • a C-ter propeptide removed in the mature form
  • secondary structure eight alplha helix and beta sheet pairs per subunit
    conjugated GlycoP , LipoP , MetalloP
    mono polymer homomer , dimer
    isoforms Precursor a signal peptide from the 1st to the 16th aa
    HOMOLOGY
    Homologene
    FAMILY peptidase M19 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • attached to the membrane by a GPI-anchor
  • brush border membrane
  • basic FUNCTION
  • hydrolyzing a wide range of dipeptides
  • playing an important role in the regulation of leukotriene activity
  • converting lekotriene D4 to leukotriene E4
  • plays a role in pancreatic cancer aggressiveness
  • functions as a positive regulator for colon cancer cell metastasis
  • zinc-dependent metalloproteinase that is fundamental in glutathione and leukotriene metabolism
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    metabolism of glutathione and its conjugates
    a component homodimer disulfide-linked
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    two ions Zn2+
    protein
  • DPEP1 promotes cancer metastasis by regulating CDH1 plasticity
  • cell & other
    REGULATION
    inhibited by by EEDQ and dansyl-ethylenediamine
    cilastatin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers (CRCs) and high DPEP1 expression levels are associated with poorer patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • excellent marker of high-grade intraepithelial neoplasia (IEN) and Colorectal cancer (CRC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    it might be a potential therapeutic target for preventing the progression of colon cancer
    cancerendocrinepancreas
    DPEP1 may be a candidate target in PDAC for designing improved treatments
    ANIMAL & CELL MODELS
    Mbd1 deficient mice