protein
| associating with the dystroglycan complex |
|
interacting with SYNM, an important IF protein in muscle cells that helps fortify the linkage between the peripheral layer of cellular myofibrils and the costameric regions located along the sarcolemma |
|
SSPN directly interacts with the utrophin-glycoprotein complex (UGC) and functions to stabilize UTRN without increasing UTRN transcription |
|
with dystrophin, bind to actin with similar affinities, and both stabilize actin filaments against depolymerization, but dystrophin and utrophin differ in their effects on the extent of lateral association with actin and in the ionic strength dependence of actin binding |
|
plays potentially a central role in the regulation of SCN5A |
|
UTRN and DMD interact with actin through their N-terminal actin-binding domain (N-ABD) |
|
SSPN regulates AKT1 signaling to control UTRN expression |
|
SSPN is a necessary component of DMD and UTRN function |
|
NFATC1-mediated transcription regulates UTRN expression and FHL1 which promotes muscle hypertrophy, is a transcriptional activator of NFATC1 |
|
DMD and UTRN are highly similar proteins that both link cortical actin filaments with a complex of sarcolemmal glycoproteins, yet localize to different subcellular domains within normal muscle cells |
|
SNTB2 controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to UTRN |