basic FUNCTION
| associating with HDAC4, HDAC in regulation of skeletal myogenesis, cardiac morphogenesis and right ventricular development and important regulator of chondrocyte gene expression |
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may be having a fundamental role in ventricular cardiomyocyte differentiation and apportioning of cells between inflow and outflow precursors in the primary heart field |
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important component in GNA13-mediated angiogenesis |
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mediating calcium-dependent transcription of the interleukin-2 gene in T lymphocytes |
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implicated in neuronal activity-dependent cell survival, and may be regulate excitatory synapse number and postsynaptic differentiation of dendrites |
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required to limit excessive increases in the number of excitatory synapses, although it does not hinder synaptogenesis seen during initial development of synaptic connectivity |
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facilitates learning and memory by negative regulation of synapse numbers and function |
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playing a crucial role in programming early neuronal differentiation and proper distribution within the layers of the neocortex |
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implicated in the regulation of adult bone mass |
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plays a pivotal role in early neuronal differentiation |
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functional cooperation of TBX5 and MEF2C links MEF2C to the higher-order protein complex regulating heart development |
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important regulator of brain, skeleton, lymphocyte and cardiovascular development and is required in the neural crest for craniofacial development |
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might serve as a potentiator of the transcriptional pathways affected in Waardenburg syndromes |
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is a transcriptional regulator of homeostasis in rod photoreceptor cells |
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GLI2 and MEF2C play important roles in the development of embryonic heart muscle and enhance cardiomyogenesis in stem cells |
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key role of MEF2C isoform in the brain, suggesting that MEF2A and MEF2D have only subtle roles in regulating hippocampal synaptic function ( |
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novel role for MEF2C/MEF2D in coordinating the transcriptional network that promotes early B-cell development |
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is a transcription factor, and critical to its function is the DNA-binding domain located at the extreme N-terminal region |
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MEF2C is highly expressed in the retina where it modulates likely photoreceptor-specific gene expression |