basic FUNCTION
| promoting survival and differentiation of subpopulations of central and peripheral neurons including several groups |
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stimulating Schwann cell migration via NCAM1 but independently of RET |
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playing an essential role in neural crest stem cell migration |
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enhancing survival and morphological differentiation of |
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dopaminergic neurons |
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increasing dopaminergic neurons high-affinity dopamine uptake |
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being a ligand for the product of the RET (rearranged during transfection) protooncogene |
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plays an important role in renal development, serving as a trophic factor for outgrowth of the ureteric bud and its continued arborisation |
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via activation of the MAPK pathway, is a fast-acting selective agent to reduce the motivation to consume and seek alcohol |
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constitutively produced by testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man |
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promotes migration of cortical neurons in a syndecan-3-dependent manner |
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required for morphogenesis of the enteric nervous system |
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mitogenic, neurotrophic, and chemoattractive to enteric neural crest cells in the embryonic colon |
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displays a dynamic expression pattern during embryonic development that parallels the chronology of migration and differentiation of neural crest derivatives in the pancreas |
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is crucial for the development of the intrinsic innervation of the pancreas |