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FLASH GENE
Symbol OXCT1 contributors: mlc - updated : 24-03-2006
HGNC name 3-oxoacid CoA transferase 1
HGNC id 8527
Corresponding disease
OXCT succinyl-CoA:3 ketoacid CoA-transferase deficiency
Location 5p13      Physical location : 41.730.167 - 41.870.791
Synonym name
  • succinyl CoA:3-oxoacid CoA transferase 1
  • 3-oxoacid CoA transferase
  • somatic-type succinyl CoA : 3-oxoacid CoA- transferase
  • Synonym symbol(s) SCOT, OXCT, Scot-S
    EC.number 2.8.3.5
    DNA
    TYPE functioning gene
    STRUCTURE 140.00 kb     17 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transit peptide
  • a CoA binding site
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Oxct1
    homolog to chicken OXCT1
    Homologene
    FAMILY 3-oxoacid CoA-transferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate
  • rate determining step of ketolysis in extrahepatic tissues, acetoacetate esterification for use in energy production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    succinylcoA metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) OXCT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS