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FLASH GENE
Symbol LIFR contributors: mct - updated : 18-09-2020
HGNC name leukemia inhibitory factor receptor
HGNC id 6597
Corresponding disease
SWS Stuve-Wiedemann syndrome
Location 5p13.1      Physical location : 38.475.064 - 38.595.507
Synonym name
  • CD118 antigen
  • LIF receptor alpha
  • Synonym symbol(s) CD118, SJS2, FLJ98106, FLJ99923, LIF-R, STWS, SWS
    DNA
    TYPE functioning gene
    STRUCTURE 131.60 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • LIFR is regulated by two alternate promoters: a placental-specific and a ubiquitously active general promoter
  • MAPPING cloned Y linked   status provisional
    Map pter - OSMR - LIFRAS - LiFR - cen
    Authors Hammarsund (2004)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 10385 - 1097 - 2019 30851421
    20 - 10540 - 1086 - 2019 30851421
    20 - 10573
    20 - 10553 - 1097 - 2019 30851421
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  highly
     male systemprostate  moderately
    Respiratoryrespiratory tractlarynx  highly
    Skeleton     
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage   
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
     chondrocyte
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytokine binding domain (CBD) with two fibronectin III domains linked by a proline-rich sequence: N-terminal fibronectin III domain of the CBD characterized by two conserved disulfide bridges, C-terminal fibronectin III domain of the CBD with a conserved WSXWS motif
  • a ligand binding domain
  • cytokine-receptor-like modules
  • one immunoglobulin-like C2 type domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Lifr
    Homologene
    FAMILY class I hematopoietin receptor family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text type 1 transmembrane protein
    basic FUNCTION
  • mediating a survival effect within oligodendrocyte and modulating severity of multiple sclerosis
  • involved in the control of osteoclast survival and size
  • functions as a novel metastasis suppressor in hepatocellular carcinoma (HCC)
  • LIFR acetylation and serine phosphorylation differentially promote stem cell self-renewal and differentiation
  • LIFR plays an oncogenic role in Prostate cancer
  • LIFR promoted adipogenic differentiation, whereas LIF may negatively regulate this process
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer LIFR/GP130 component of the endogenous defense against inflammatory CNS injury
  • quaternary cytokine receptor complex consisting of IL6ST, LIFR, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTFRA)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Neuropoietin activates STAT3 independent of LIFR activation in adipocytes
  • NEGR1 interacts with leukemia inhibitory factor receptor (LIFR) and modulates LIF-induced LCN2 expression
  • cell & other
    REGULATION
    inhibited by SOCS3 (LIFR signaling is under tight negative regulation by the intracellular protein suppressor of cytokine signaling 3 (SOCS3))
    ASSOCIATED DISORDERS
    corresponding disease(s) SWS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    deactivating LIFR mutations cause highly similar anomalies of the urogenital tract
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate therapeutic strategy for demyelinating disease
    Marker
  • is possibly a valuable prognostic marker for Colorectal cancer
  • may serve as a prognostic biomarker for Hepatocellular carcinoma (HCC) patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    could be a potential therapeutic target for CRC
    ANIMAL & CELL MODELS