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FLASH GENE
Symbol CD8A contributors: mct/npt - updated : 28-03-2012
HGNC name CD8a molecule
HGNC id 1706
Location 2p11.2      Physical location : 87.011.728 - 87.035.519
Synonym name
  • CD8 antigen, alpha polypeptide (p32)
  • Leu2 T-lymphocyte antigen
  • OKT8 T-cell antigen
  • T cell co-receptor
  • cell differentiation antigen CD8A (p32), class I receptor, identified by monoclonal antibodies T8, Leu2a, M236, UCHT4, T811
    • Synonym symbol(s) CD8, LEU2, MAL, p32
    DNA
    TYPE functioning gene
    STRUCTURE 7.11 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map pter - CD8A - IGKC IGKC - IGKJ@ - IGKV@ - cen
    Authors Weichhold (93)
    Physical map
    MAT2A 2p11.2 methionine adenosyltransferase II, alpha GGCX 2p12 gamma-glutamyl carboxylase VAMP8 2p11.2-p11.1 vesicle-associated membrane protein 8 (endobrevin) VAMP5 2p11.2 vesicle-associated membrane protein 5 (myobrevin) LOC51255 2p11.2 hypothetical protein LOC51255 FLJ90024 2p11.2 fasting-inducible integral membrane protein TM6P1 LOC388969 2 LOC388969 USP39 2p11.2 ubiquitin specific protease 39 SFTPB 2p12-p11.2 surfactant, pulmonary-associated protein B GNLY 2p12-q11 granulysin HATH6 SIAT9 2p11.2 sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase) POLR1A 2p11.2 polymerase (RNA) 1 polypeptide A, 194kDa FLJ20758 2p11.2 FLJ20758 protein IMMT 2p11.2 inner membrane protein, mitochondrial (mitofilin) MRPL35 2p11.2 mitochondrial ribosomal protein L35 FLJ13110 2p11.2 hypothetical protein FLJ13110 JMJD1 2p11.2 jumonji domain containing 1 NEDF 2p24.3-p24.1 neuroendocrine differentiation factor RNF103 2p11.2 ring finger protein 103 FLJ13910 2p11.2 hypothetical protein FLJ13910 CD8A 2p12 CD8 antigen, alpha polypeptide (p32) CD8B1 2p12 CD8 antigen, beta polypeptide 1 (p37) LOC388970 2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) PLGL 2p11-q11 plasminogen-like LOC388971 2 LOC388971 LOC285069 2p11.1 hypothetical protein LOC285069 LOC115281 2p11.2 similar to Ig kappa variable region MGC4677 2p11.2 hypothetical protein MGC4677 LOC388972 2 similar to anaphase-promoting complex 1 (meiotic checkpoint regulator) LOC388973 2 similar to plasminogen-like LOC388974 2 similar to RAN-binding protein 2-like 1 isoform 1; sperm membrane protein BS-63; RAN-binding protein 2-like 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3035 - 235 - 2007 17678538
    5 - 2924 - 198 - 2007 17678538
    - - 3177 - 235 - 2007 17678538
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   predominantly
     thymus   predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • enhancing formation of stable T-cell receptor/MHC class I complexes
  • enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I, favoring lipid raft partitioning of TCR, and inducing intracellular signaling
  • interplay between CD8A+ dendritic cells and monocytes in response to Listeria monocytogenes infection attenuates T cell responses
  • its expression is tightly controlled during T-cell development by the activity of five CD8 enhancers (E8(I)-E8(V)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component with CD8B, forms CD8alphabeta heterodimer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with NFIL3 (plays an essential role in the development of CD8A(+) conventional dendritic cells)
  • interacting with LNX1 or LNX2 (LNX1 or LNX2 promoted CD8A ubiquitylation, downregulation from the plasma membrane, transport to the lysosomes, and degradation)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS