basic FUNCTION
| receptor controlling the production, differentiation, and function of granulocytes |
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may also function in some cell surface adhesion or recognition processes |
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is required for SHP1 downregulation of CSF3-induced STAT activation |
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critical regulator of granulopoiesis |
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CSF3R signaling participates in the production of neutrophilic granulocytes during normal hematopoietic development, with a particularly important role during emergency hematopoiesis |
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possible role of CSF3 in malignant transformation, particularly in patients with neutropenia harboring mutations in the gene encoding the CSF3R |
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its ubiquitination is crucial for lysosomal routing and degradation |
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CSF3R signaling interacts with RARs in the regulation of myeloid differentiation |
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tight control between activation and attenuation of granulocyte colony stimulating factor receptor (CSF3R) signaling is essential to regulate survival, proliferation and differentiation of myeloid progenitor cells |