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Symbol ATF2 contributors: mct/pgu - updated : 12-07-2017
HGNC name activating transcription factor 2
HGNC id 784
Location 2q31.1      Physical location : 175.939.007 - 176.032.897
Synonym name
  • cAMP responsive element binding protein 2
  • activating transcription factor 2 splice variant ATF2-var2
  • cAMP response element-binding protein CRE-BP1
  • Synonym symbol(s) CREB2, HB16, CREBP1, MGC111558, TREB7, CRE-BP1
    TYPE functioning gene
    STRUCTURE 93.90 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC389062 2 LOC389062 LOC391462 2 similar to protein 40kD PTD004 2q31.1 hypothetical protein PTD004 LOC391463 2 similar to Leucine-rich repeat-containing protein 2 LOC389063 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) LOC389064 2 hypothetical gene supported by AK128215 CIR 2q31.1 CBF1 interacting corepressor SES3 2q31.1 secernin 3 GPR155 2q31.1 G protein-coupled receptor 155 WASPIP 2q31.1 Wiskott-Aldrich syndrome protein interacting protein LOC151561 2q31.2 similar to H3 histone, family 3B CHRNA1 2q31-q32 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) CHN1 2q31-q32.1 chimerin (chimaerin) 1 ATF2 2q32 activating transcription factor 2 ATP5G3 2q31.1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3 LOC391464 2 similar to 40S ribosomal protein S15a KIAA1715 2q31 KIAA1715 LOC344191 2q31.2 similar to Homeobox even-skipped homolog protein 2 (EVX-2)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3300 60 463 - 2003 12909347
  • an incomplete N-terminal domain, and a novel C-terminal region, but an intact bZIP domain
  • a 97-bp internal deletion in the coding region, and a unique 3' region
  • potential regulator of the human DNA polymerase promoter
  • 14 - 2117 54.4 505 - 2009 19331149
    - - - - - - 2005 15691875
    role in the myometrium
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Digestiveliver   highly
    Nervousbrain   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • basic leucine zipper (bZIP) protein
  • zinc finger motif
  • proline-rich motif
  • mono polymer homomer , heteromer , dimer
    interspecies homolog to murine Atf2
    intraspecies homolog to ATF7
  • bZIP family
  • ATF subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • regulates transcription in response to stress and growth factor stimuli
  • mediating the E1A responsiveness
  • acting as a tumor supressor gene in lung cancer
  • playing an important role in the mediation of cellular stress responses, development and transformation
  • having a suppressor activity in skin tumor formation
  • activates the transcription of apoptosis-related genes
  • may be a key regulator of the insulin promoter possibly stimulating activity in response to extracellular signals
  • transcription factor important for normal cellular development and survival
  • in cooperation with mutated oncogenes or tumor suppressor genes, can also elicit tumor suppressor function
  • may be a key regulator of the insulin promoter possibly stimulating activity in response to extracellular signals
  • importance of transcriptionally active ATF2 in melanoma development through fine-tuning of MITF expression (
  • ATF2 was required for other endothelial cell outputs, such as cell migration and tubulogenesis
  • CELLULAR PROCESS nucleotide, transcription
    a component
    DNA binding
    small molecule
  • cAMP response element of many viral and cellular proteins
  • CNTN2 (for activation HTLV-1 promoter)
  • DDIT3
  • interacting with NCOA6 by its N-terminal transactivation domain to induce target gene transcription during granulocytic differentiation
  • binding CRE2 site of INS
  • binds directly to both MAPKAP1 and MAPK14
  • regulating ATM activation by control of KAT5 stability and activity
  • interacts with beta-cell-enriched transcription factors, MAFA, PDX1, and NEUROD1, and activates insulin gene transcription
  • ATF2 likely functionally required for VEGFA-stimulated endothelial VCAM1 gene expression
  • cell & other
    activated by virus
    mitogen activated protein kinase (MAPK) pathways
    stress and growth factors that activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain
    inhibited by polyamines (negatively regulate ATF2 expression posttranscriptionally and polyamine depletion stabilizes ATF2 mRNA by enhancing the interaction of the 3prime-untranslated region (UTR) of ATF2 with cytoplasmic ELAVL1)
    Other phosphorylated by MAPK14/Jun NH2-terminal protein kinase
    phosphorylated at Serine 121 by protein kinase C (controls c-Jun-mediated activation of transcription)
    the MEKK/MKK7/JNK2 module is responsible for ATF2 phosphorylation
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in skin carcinogenesis
    tumoral     --over  
    associated with prolonged survival in mammary carcinoma
    Variant & Polymorphism
    Candidate gene
    Therapy target