basic FUNCTION
| messenger RNA CAP binding protein |
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translation initiation factor that binds to the cap structure and is part of a complex (eIF-4F) that promotes mRNA binding to ribosomes |
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also involved in a nuclear function |
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translational regulator acting downstream of AKT1 and FRAP1 in oncogenesis and drug resistance |
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EIF4EBP1, EIF4EBP2 regulate the Stress granules (SGs) localization of EIF4E |
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central node in a RNA regulon that modulates the expression of genes involved in proliferation and survival |
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controls gene expression through its effects on mRNA export and cap-dependent translation, both of which contribute to its oncogenic potential |
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plays a key role in learning and memory through its control of translation within the synapse |
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can rescue both cell cycle progression and Ras-induced transformation in RND3-expressing cells, indicating that the inhibition of eIF4E function is critical to mediate the anti-proliferative effects of RND3 |
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PARK2 and EIF4E act in a common pathway, likely modulating cap-dependent translation initiation events |
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key role for the MKNK1, MKNK2/EIF4E pathway in the regulatory effects of IFNG on normal hematopoiesis |
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co-ordinative roles for DDX3X, EIF4E and PABPC1 in integrating environmental stress with translational regulation |
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serves as a master switch that controls eukaryotic translation |
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activity of EIF4E is under homeostatic control via the regulation of the levels of its repressor protein EIF4EBP1 through ubiquitination |
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important role of EIF4EBP2 and EIF4E in postsynaptic translational control of neuronal mRNAs |
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translational control by EIF4E regulates the synthesis of neuroligins, maintaining the excitation-to-inhibition balance, and its dysregulation engenders ASD-like phenotypes |
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EIF4E3 repressed the expression of a pool of target mRNAs common with EIF4E |
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represses target expression and oncogenic transformation, in direct contrast to EIF4E, which stimulates these processes |
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EIF4E, EIF4E2, and EIF4E3, are essential for translation initiation |
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the formation of the ANGEL1/EIF4E complex is independent of the MTOR signaling pathway and its downstream target EIF4EBP1 |
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unphosphorylated HSPB1 associates with EIF4E in osteoblasts and suppresses the translation initiation process |
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EIF4E plays a pivotal role in the control of cap-dependent translation initiation, modulates the fate of specific mRNAs, occurs in processing bodies (PBs) and is required for formation of stress granules (SGs) |
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EIF4E acts in the nuclear export and translation of a subset of mRNAs, and these functions contribute to its oncogenic potential |
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EIF4G, EIF4E, EIF4A, and EIF4B, facilitate the recruitment of mRNA onto the preassembled 43S pre-initiation complex (PIC), thus leading to the formation of the 48S PIC |