basic FUNCTION
| cell surface proteoglycan bearing both heparan sulfate and chondroitin sulfate and linking the cytoskeleton |
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to the interstitial matrix |
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involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling |
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playing an essential role in maintaining intestinal epithelial barrier function |
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physiological binding partner of TIAM1 and the PDZ domain has a function in cell-matrix adhesion and cell migration |
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regulates mesenchymal tumor cell adhesion and migration, and its different domains have differential effects |
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is a regulator of focal adhesion disassembly in migrating lung epithelial cells |
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cell surface proteoglycan that can organize co-receptors into a multimeric complex to transduce intracellular signals |
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in the germinal niche is a key regulator of the maintenance and proliferation of neural progenitor cells (NPCs) during cortical neurogenesis |
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promotes vascular smooth muscle cells (vSMCs) differentiation and quiescence |
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modulates the motility and resolution responses of macrophages |
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role of the syndecan (SDC1) heparan sulphate proteoglycans, the small intracellular adaptor SDCBP and associated regulators in the biogenesis and loading of exosomes with cargo |
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may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production |
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soluble (shed) form of SDC1 has paracrine and autocrine functions and is normally produced in a regulated fashion |