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FLASH GENE
Symbol GPX8 contributors: mct - updated : 24-09-2019
HGNC name glutathione peroxidase 8 (putative)
HGNC id 33100
Location 5q11.2      Physical location : 54.455.983 - 54.463.129
Synonym symbol(s) GPx-8, UNQ847, EPLA847, GSHPx-8
EC.number 1.11.1.9
DNA
TYPE functioning gene
STRUCTURE 7.14 kb     3 Exon(s)
regulatory sequence Promoter
Binding site   HRE
text structure
  • two hypoxia-response elements (HREs) within the promoter, GPX8 HRE1 and GPX8 HRE2
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3731 - 209 - 2015 25557012
    2 - 3469 - 90 - 2015 25557012
    3 - 3578 - 158 - 2015 25557012
    3 - 3452 - 116 - 2015 25557012
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved N-terminal transmembrane domain (TMD)
  • a C-terminal KDEL-like motif for ER localization
  • HOMOLOGY
    intraspecies homolog to GPX7
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • is enriched in mitochondria-associated membranes and regulates Ca2+ storage and fluxes
  • type-II transmembrane peroxidase enriched at the mitochondria-associated endoplasmic reticulum membrane
  • basic FUNCTION
  • GPX7 and GPX8 may represent a novel route for the productive use of peroxide produced by ERO1A during disulfide bond formation
  • Cys-glutathione peroxidase of the endoplasmic reticulum membrane, involved in protein folding
  • GPX7 and GPX8 are unique homologs that contain a peroxidatic Cys (CP)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS