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FLASH GENE
Symbol TRABD2B contributors: mct - updated : 30-10-2017
HGNC name TraB domain containing 2B
HGNC id 44200
Location 1p33      Physical location : -
Synonym name
  • TRAB domain-containing protein 2B
  • UPF0632 protein A
  • Synonym symbol(s) TIKI2
    DNA
    TYPE functioning gene
    STRUCTURE 23.68 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 7029 - 517 - 2016 26631728
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure two pairs of potential disulfide bonds that reside outside the beta-sheet catalytic core but likely assist the folding of the TIKI domain
    conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to TRABD2A
    Homologene
    FAMILY Tiki family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • TRABD2A, TRABD2B exhibit specific expression during embryogenesis
  • mis-regulation of TRABD2A, TRABD2B in human cancer and diseases
  • TRABD2A, TRABD2B, are Wnt inhibitors that act by cleaving the Wnt amino-terminal region to inactivate specific Wnt ligands
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRABD2A, TRABD2B result in a WNT3A modification that minimizes Wnt3a activity but not secretion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of TRABD2A, TRABD2B in osteosarcoma may participate in the progression of osteosarcoma and restoring its expression was able to impair the growth of osteosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS