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FLASH GENE
Symbol MZB1 contributors: mct - updated : 15-03-2016
HGNC name marginal zone B and B1 cell specific protein
HGNC id 30125
Location 5q31.2      Physical location : -
Synonym name
  • caspase-2 binding protein
  • plasma cell-induced ER protein 1
  • mesenteric estrogen-dependent adipose 7
  • proapoptotic caspase adaptor protein
  • Synonym symbol(s) MEDA-7, PACAP, pERp1
    DNA
    TYPE functioning gene
    STRUCTURE 2.35 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 845 - 189 - 2010 21093319
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a thioredoxin-like active site motif (CXXC), which is the signature of oxidoreductases
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation
  • is important for B cell function as a key regulator of antibody secretion, calcium homeostasis and adhesion
  • due to its biological function, MZB1 may play a central role in B cell neoplasms
  • B-cell-specific and endoplasmic reticulum (ER)-localized protein implicated in antibody secretion and integrin-mediated cell adhesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MZB1 associates directly with the substrate-specific chaperone HSP90B1 in an ATP-sensitive manner and is required for the interaction of HSP90B1 with immunoglobulin heavy chain upon ER stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS