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FLASH GENE
Symbol SIMC1 contributors: mct - updated : 11-04-2014
HGNC name SUMO-interacting motifs containing 1
HGNC id 24779
Location 5q35.2      Physical location : -
Synonym name
  • platform element for inhibition of autolytic degradation
  • chromosome 5open reading frame 25
  • Synonym symbol(s) C5orf25, OOMA1, PLEIAD
    DNA
    TYPE functioning gene
    STRUCTURE 107.62 kb     12 Exon(s)
    text structure composed of 12 exons, of which exon 3 encodes the canonical first Met
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2087 - 457 - 2013 23707407
    10 - - - - predominant variant in skeletal muscle, not identified in other human tissues, such as brain or testis 2013 23707407
    lacks exons 2 and 3
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivemale systemtestis    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region interacts with CTBP1
  • C-terminal sequence, which harbors the CAPN3 inhibitory or regulatory activity
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text primarily distributed diffusely in the cytoplasm
    basic FUNCTION
  • can shift its major function from CAPN3 suppression to CAPN3-substrate recruitment, depending on the cellular context
  • novel suppressor and scaffold for CAPN3, scaffolds CAPN3 to direct and regulate its substrate-proteolyzing activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a CAPN3-binding protein and suppresses the protease activity of CAPN3
  • also interacts with CTBP1 (C-terminal binding protein 1), a transcriptional co-regulator
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS