Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WDR60 contributors: mct - updated : 15-10-2016
HGNC name WD repeat domain 60
HGNC id 21862
Corresponding disease
SRPS6 short rib-polydactyly syndrome type 6
Location 7q36.3      Physical location : 158.649.268 - 158.738.882
Synonym symbol(s) tcag7.557
DNA
TYPE functioning gene
STRUCTURE 89.61 kb     25 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 3789 - 1066 - 2013 2391046
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four WD40 repeat domains
  • two coiled-coil domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localizes at the base of the primary cilium in chondrocytes
  • basic FUNCTION
  • potential role for WDR60 in ciliogenesis
  • possible role in regulating the specialized trafficking process of cilia
  • TCTEX1D2 and WDR60 were stable throughout the cell cycle, associated with dynein, and localized to the microtubule organizing center in a microtubule-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TCTEX1D2 associates with WDR34, WDR60, and other subunits of DYNC1 and DYNC2 and colocalizes with WDR60 to microtubule organizing centers during interphase
  • WDR60 plays a major role and DYNLT2B plays an auxiliary role in the dynein-2 complex to mediate retrograde ciliary protein trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRPS6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS