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FLASH GENE
Symbol NKX6-3 contributors: mct - updated : 04-07-2013
HGNC name NK6 homeobox 3
HGNC id 26328
Location 8p11.21      Physical location : 41.503.828 - 41.504.878
Synonym name
  • NK6 transcription factor related, locus 3
  • Synonym symbol(s) FLJ25169
    DNA
    TYPE functioning gene
    STRUCTURE 1.05 kb
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 551 - 135 - 2006 16326147
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomachpylorus    Homo sapiens
     stomach     Homo sapiensFetal
    Nervousbrainhindbrain    Homo sapiens
     brain     Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiensAdult
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY Nkx6 subfamily of homeodomain proteins
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • overlaps NKX6.1 and NKX6.2 in expression in the hindbrain and stomach
  • implicated as a selective regulator of G- and D-cell lineages, which are believed to derive from a common progenitor, and suggest that it operates in parallel with NEUROG3
  • its function is dispensable for CNS development and lead to the proposal that absence of overt defects is due to functional compensation from a related homeodomain transcription factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nkx6.3 null embryonic mouse hindbrain did not reveal detectable defects in progenitor markers, motor neuron or V2 interneuron sub-types