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FLASH GENE
Symbol HOTS contributors: mct - updated : 24-10-2012
Location 1p15.5      Physical location : -
Genatlas name H19 opposite tumor suppressor
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text
  • transcribed in antisense orientation to the H19 gene (
  • MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 17 150 - 2011 21940503
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly Homo sapiens
    Nervousbrain   highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING paternally
    text maternally expressed
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • localizes to the nucleus and nucleolus
  • basic FUNCTION
  • primate-conserved, ubiquitous transcript antisense to H19
  • polysome-associated RNA encoding a nucleolar protein
  • may mediate its tumor suppressor activity by targeting DNA replication and cell cycle regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the enhancer of rudimentary homolog (ERH) protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    inhibits Wilms, rhabdoid, rhabdomyosarcoma, and choriocarcinoma tumor cell growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS