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FLASH GENE
Symbol UBA6 contributors: shn - updated : 19/05/2015
HGNC name ubiquitin-like modifier activating enzyme 6
HGNC id 25581
Location 4q13.2      Physical location : 68.481.479 - 68.566.889
Synonym name
  • ubiquitin-activating enzyme E1-like 2
  • UBA6, ubiquitin-activating enzyme E1
  • ubiquitin-activating enzyme E1
  • monocyte protein 4
  • ubiquitin-activating enzyme 6
  • ubiquitin-activating enzyme E1-like protein 2
  • ubiquitin-like modifier-activating enzyme 6
  • Synonym symbol(s) UBE1L2, FLJ10808, E1-L2, FLJ23367, MOP-4
    DNA
    TYPE
    STRUCTURE 85.41 kb     33 Exon(s)
    MAPPING cloned   linked   status confirmed
    Map cen - D4S2367 - D4S409 - UBA6 - D4S3018 - D4S2387 - qter
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 6462 1052 - - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   lowly Homo sapiens
     liver   lowly Homo sapiens
    Lymphoid/Immunelymph node   lowly Homo sapiens
     spleen   lowly Homo sapiens
     thymus   lowly Homo sapiens
    Nervousbrain   lowly Homo sapiens
    Reproductivefemale systemovary  lowly Homo sapiens
     female systemuterus  lowly Homo sapiens
     male systemtestis  predominantly Homo sapiens
    Respiratorylung   lowly Homo sapiens
    Urinarykidney   lowly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ATP-binding domain (
  • an active site cysteine conserved among E1 family proteins (
  • C-terminal ubiquitin-fold domain (
  • HOMOLOGY
    interspecies homolog to Uba1
    ortholog to Uba6, Mus musculus
    ortholog to Uba6, Rattus norvegicus
    ortholog to UBA6, Pan troglodytes
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • activates ubiquitin (
  • required for charging a uncharacterized Uba6-specific E2 , Use1 (
  • activates both ubiquitin and FAT10, and plays an important role in embryogenesis (
  • functions with the UBR1-3 subfamily of N-recognin E3s to degrade the N-end rule substrates RGS4, RGS5, and Arg (R)-GFP 5 (
  • undergo a three-step activation process and form a ternary complex with both UBLs, similar to what has been observed for UBA1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ubiquitin (
  • UBD conjugation, a post-translational modification analogous to ubiquitination, specifically requires UBA6 and UBE2Z as its activating (E1) and conjugating (E2) enzymes
  • novel function of LMO2 involving in the regulatory hierarchy of UBA6-USE1-FAT10ylation pathway by targeting the E1 enzyme UBA6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse deleted for the first two exons of Uba6 gene exibits embryonic lethality (