basic FUNCTION
| required for chromosomal DNA replication |
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promotes initiation of chromosomal DNA replication in multicellular organisms by mediating TOPBP1- and CDK2-dependent recruitment of CDC45 onto replication origins |
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implicated in the cell cycle and is required for DNA replication |
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MCI, GMNN, and GMNC may have arisen in vertebrates through duplication of an ancestral Geminin-like gene |
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MCIDAS and GMNC are key players in the generation of multiciliated ependymal cells of the adult neurogenic niche |
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is an essential regulator of ciliogenesis in the airway epithelium and a candidate gene for mucociliary disorders |
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MCIDAS and GMNC/Lynkeas are key players on radial glial specification to ependymal cells |
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GMNC and MCIDAS specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors to switch on a gene expression program leading to centriole amplification and cilia formation |
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required for multiciliated cells (MCCs) formation |
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mlticiliated cells (MCC) differentiation program is initiated by GMNC and MCIDAS, that activate key transcription factors, including p73 and FOXJ1, to control the multiciliogenesis program |