basic FUNCTION
| displays an oscillatory expression profile in Brown adipose tissue and liver, consistent with a circadian rhythm |
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plays potentially a role in adaptive thermogenesis |
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is potentially a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment |
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critical mediator of TM (Tunicamycin) toxicity, and having a critical role by acting as a putative TM transporter at the plasma membrane |
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is a nutritionally regulated gene that plays myriad roles in body growth and development, motor function, and lipid metabolism |
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is a key regulator of BBB function that may act by suppressing transcytosis in CNS endothelial cells |
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is required for brain uptake of docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function |
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is specifically expressed on the cell membrane of brain-microvascular endothelial cell (BMEC) and is implicated in the delivery of some substances across the blood-brain barrier (BBB) |
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sodium-dependent lysophosphatidylcholine transporter expressed at the blood-brain barrier endothelium |
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uniquely transports lipids, implying that MFSD2A harbors unique structural features and transport mechanism |
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is essential for sphingosine-1-phosphate (S1P) export from endothelial cells in the brain |