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FLASH GENE
Symbol LYPD1 contributors: mct - updated : 21-09-2011
HGNC name LY6/PLAUR domain containing 1
HGNC id 28431
Location 2q21.2      Physical location : 133.402.337 - 133.429.070
Synonym symbol(s) LYNX2, PSEC0181, FLJ41033, LYPDC1, MGC29643, PHTS
DNA
TYPE functioning gene
STRUCTURE 26.73 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1974 - 89 - 2006 16413018
3 - 2683 - 141 - 2006 16413018
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral  highly Homo sapiens
Nervousperipherous  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY Ly-6/neurotoxin superfamily
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
text expressed in postmitotic central and peripheral neurons
basic FUNCTION
  • may function in a new and TP53-independent tumor suppressor pathway
  • important component of the molecular mechanisms that control anxiety
  • membrane-tethered proteins LYNX1 and LYPD1 are co-localized with some CHRNA subtypes and modulate their activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can bind to and modulate neuronal nicotinic receptors, and loss of LYPD1 alters the actions of nicotine on glutamatergic signaling in the prefrontal cortex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    altered glutamatergic signaling in the prefrontal cortex of Lynx2 mutant mice contributes to increased anxiety-related behaviors