basic FUNCTION
| FTY720-P (a new class of immunosuppressors that has been approved as a novel oral therapeutic drug for multiple sclerosis) transporter in cells |
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can transport S1P analogues accumulated inside cells, but only transports phosphorylated sphingolipids |
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SPNS2 is an S1P transporte that plays a role in regulation not only of blood S1P but also lymph node and lymph S1P levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization |
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plays key roles in regulating the cellular functions in non-small cell lung cancer (NSCLC) cells |
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broad role for SPNS2-mediated S1P transport in the initiation and development of adaptive immune related disorders |
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SPNS2 is indispensable for normal retinal morphogenesis |
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S1P transporter, promoting microglia pro-inflammatory activation |
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SPNS2 activates microglia inflammation through, at least partially, NF& |
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954;B pathway |
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SPNS2 promotes likely pro-inflammatory polarization of microglia and may play a crucial role in Alzheimer disease pathogenesis |
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SPNS2 transporter contributes to the accumulation of S1P in Cystic Fibrosis human bronchial epithelial cells |
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role of SPNS2 in corneal and Meibomian gland morphogenesis |