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FLASH GENE
Symbol ZNF580 contributors: mct - updated : 31-08-2010
HGNC name zinc finger protein 580
HGNC id 29473
Location 19q13.42      Physical location : 56.152.391 - 56.154.835
Synonym name LDL induced EC protein
DNA
TYPE functioning gene
STRUCTURE 2.45 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1046 18.8 172 - Sun (2010)
1 - 1433 18.8 172 - Sun (2010)
2 - 1152 18.8 172 - Sun (2010)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three repeated tandem C2H2-type zinc finger motifs at its C-terminus
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text could localize into the nuclei (Sun 2010)
    basic FUNCTION
  • important role in the process of migration and proliferation of endothelial cells, which provides a foundation for a novel approach to regulate angiogenesis (Sun 2010)
  • may be involved in transcriptional regulation of angiogenesis (Sun 2010)
  • mediates S1P/MAPK14 signaling to promote endothelial cell migration and proliferation (Sun 2010)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ZN2+
    • protein
  • associated with LDL stimulation in vascular endothelial cells (Sun 2010)
  • regulates MMP2 expression in endothelial cells (MMP2 mRNA expression and its enzymatic activity was correlated with the expression of ZNF580)(Sun 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS