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FLASH GENE

Symbol

ULK3

contributors: mct - updated : 16-02-2011

HGNC name	unc-51-like kinase 3 (C. elegans)
HGNC id	19703

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q24.1      Physical location : 75.128.458 - 75.135.552
Synonym symbol(s)	DKFZP434C131, FLJ90566
EC.number	2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	7.09 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001099436 16 - 2635 NP_001092906 - 472 - 2010 19878745

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive liver       highly   stomach       lowly Endocrine adrenal gland       moderately Lymphoid/Immune thymus       lowly Nervous brain       highly Reproductive female system placenta     lowly   male system testis     moderately   male system prostate     lowly Respiratory lung       lowly Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	highly in brain, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two MIT domains
	one protein kinase domain

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Ulk3 (94.1pc)
	homolog to rattus Ulk3 (94.6pc)

Homologene

FAMILY	protein kinase superfamily
	Ser/Thr protein kinase family
	APG1/unc-51/ULK1 subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	protein serine/threonine kinase activity
	able to regulate GLI proteins positively in a kinase activity-dependent manner
	involved in the SHH pathway as a positive regulator of GLI proteins
	phosphorylation of GLI1 by ULK3 results in GLI1 nuclear accumaltion
	participates in the transduction of the SHH signal also independently of its kinase activity
	a potential dual function in the SHH signal transduction pathway and an additional way of regulating GLI proteins by SUFU, through binding to and suppression of ULK3
	able to enhance the activity of GLI1 and GLI2 proteins in a kinase activity-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

through its kinase domain interacts with Suppressor of Fused (SUFU), a protein required for negative regulation of Gli proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   induces autophagy and senescence

Susceptibility

Variant & Polymorphism SNP	SNp is associated with blood pressure and/or hypertension in the Japanese

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS