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FLASH GENE

Symbol

THEMIS

contributors: mct/npt - updated : 05-01-2010

HGNC name	thymocyte selection associated
HGNC id	21569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q22.33      Physical location : 128.029.339 - 128.239.776
Synonym name	thymocyte-expressed molecule involved in selection
	Grb2-associating protein
	chromosome 6 open reading frame 207
	chromosome 6 open reading frame 190
	thymocyte selection pathway associated
Synonym symbol(s)	C6orf190, C6orf207, GASP, FLJ40584, MGC163388, TSEPA, bA325O24

DNA

TYPE	functioning gene
STRUCTURE	210.40 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001010923 7 - 3866 NP_001010923 - 641 - Fu (2009) NM_001164687 - - 3830 NP_001158159 - 606 - Fu (2009) NM_001164685 - - 3983 NP_001158157 - 680 - Lu (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus cortex     specific

cell lineage	high expression in thymocytes between the pre-T cell antigen receptor (pre-TCR) and positive-selection checkpoints and low expression in mature T cells (Fu 2009)
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal Src homology 3 domain

HOMOLOGY

Homologene

FAMILY

themis family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	cytosolic protein (Patrick 2009)

basic FUNCTION	phosphorylated quickly after TCR stimulation and needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk, and involved in TCR signaling (Fu 2009)
	critical component of the T cell developmental program and may functions to sustain and/or integrate signals required for proper lineage commitment and maturation (Lesourne 2009)
	T cell-specific protein important for late thymocyte development (Lesourne 2009)
	playing a a unique function in sustaining positive selection (Johnson 2009)
	may acts as a thymocyte-specific adaptor for GRB2 or regulates Ras signaling in double positive thymocytes (Patrick 2009)
	critical in positive selection but not in other TCR-related signal transduction events (Patrick 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

constitutively associates with GRB2 via its N-terminal Src homology 3 domain (Patrick 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS