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FLASH GENE
Symbol THEMIS contributors: mct/npt - updated : 05-01-2010
HGNC name thymocyte selection associated
HGNC id 21569
Location 6q22.33      Physical location : 128.029.339 - 128.239.776
Synonym name
  • thymocyte-expressed molecule involved in selection
  • Grb2-associating protein
  • chromosome 6 open reading frame 207
  • chromosome 6 open reading frame 190
  • thymocyte selection pathway associated
  • Synonym symbol(s) C6orf190, C6orf207, GASP, FLJ40584, MGC163388, TSEPA, bA325O24
    DNA
    TYPE functioning gene
    STRUCTURE 210.40 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3866 - 641 - Fu (2009)
    - - 3830 - 606 - Fu (2009)
    - - 3983 - 680 - Lu (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymuscortex  specific
    cell lineage high expression in thymocytes between the pre-T cell antigen receptor (pre-TCR) and positive-selection checkpoints and low expression in mature T cells (Fu 2009)
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal Src homology 3 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • themis family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text cytosolic protein (Patrick 2009)
    basic FUNCTION
  • phosphorylated quickly after TCR stimulation and needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk, and involved in TCR signaling (Fu 2009)
  • critical component of the T cell developmental program and may functions to sustain and/or integrate signals required for proper lineage commitment and maturation (Lesourne 2009)
  • T cell-specific protein important for late thymocyte development (Lesourne 2009)
  • playing a a unique function in sustaining positive selection (Johnson 2009)
  • may acts as a thymocyte-specific adaptor for GRB2 or regulates Ras signaling in double positive thymocytes (Patrick 2009)
  • critical in positive selection but not in other TCR-related signal transduction events (Patrick 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • constitutively associates with GRB2 via its N-terminal Src homology 3 domain (Patrick 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS