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FLASH GENE
Symbol GYPC contributors: mct - updated : 28-11-2018
HGNC name glycophorin C (Gerbich blood group)
HGNC id 4704
Corresponding disease
GRBG blood group--Gerbich
Location 2q14.3      Physical location : 127.413.683 - 127.454.245
Synonym name
  • glycoconnectin
  • glycophorin-D
  • sialoglycoprotein-D
  • CD236 antigen
  • Synonym symbol(s) GLYC, GPC, GYPD, Ge, CD236, CD236R, GPD, MGC117309, MGC126191, MGC126192, PAS-2
    DNA
    TYPE functioning gene
    STRUCTURE 40.74 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1249 13.7 128 - 2003 12469115
    3 - 1192 11.8 109 - 2003 12469115
    5 - 2067 - 107 - 2003 12469115
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeanterior segment   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text type3 membrane protein
    basic FUNCTION
  • plasmodium falciparum receptor, playing an important role in regulating the stability of red cells
  • encodes two erythrocyte surface sialoglycoproteins in humans, glycophorin C and glycophorin D (GYPC and GYPD), via initiation of translation at two start codons on a single transcript
  • crucial role of GYPC for P. berghei infection
  • GYPA, GYPB receptor are of greater importance than the GYPC receptor, supporting a hierarchy of erythrocyte receptor usage in P. falciparum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GRBG
    related resource Blood Group Antigen Mutation Database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS