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Symbol GYPB contributors: mct - updated : 28-11-2018
HGNC name glycophorin B (MNS blood group)
HGNC id 4703
Corresponding disease
MNS MNS blood group
Location 4q31.21      Physical location : 144.917.256 - 144.940.496
Synonym name
  • glycophorin B (includes Ss blood group)
  • SS-active sialoglycoprotein
  • glycophorin A
  • glycophorin HeP2
  • glycophorin MiVI
  • sialoglycoprotein delta
    • Synonym symbol(s) SS, MNS, CD235b, GPB, GPB.NY, GYPA, GYPHe.NY, HGpMiVI, PAS-3
    DNA
    TYPE functioning gene
    STRUCTURE 26.70 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 529 7.7 91 - 2017 28760933
    6 - 609 - 65 - 2017 28760933
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • carbohydrate rich sialoglycoprotein
    • conjugated GlycoP , Other
    HOMOLOGY
    interspecies homolog to C.elegans F26E4.6
    intraspecies paralog to GYPA
    Homologene
    FAMILY
  • glycophorin A family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • GYPA, GYPB receptor are of greater importance than the GYPC receptor, supporting a hierarchy of erythrocyte receptor usage in P. falciparum
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component major protein constituent of erythrocyte membrane
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DUP4 is a complex structural genomic variant that carries extra copies of GYPA-GYPB fusion gene and has a dramatic effect on malaria risk by reducing the risk of severe malaria by up to 40p100
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MNS
    related resource Blood Group Antigen Mutation Database
    Susceptibility to variable risk of severe malaria
    Variant & Polymorphism other
  • DUP4 variant confers a clinically important protective effect, with carriers &
    • 8764;40p100 less likely to develop cerebral malaria
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS