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FLASH GENE
Symbol SMDT1 contributors: mct - updated : 30-05-2016
HGNC name single-pass membrane protein with aspartate-rich tail 1
HGNC id 25055
Location 22q13.2      Physical location : -
Synonym name
  • chromosome 22 open reading frame 32
  • hypothetical protein LOC91689
  • essential MCU regulator, mitochondrial
    • Synonym symbol(s) dJ186O1.1, DDDD, C22orf32, EMRE, dJ186O1.1
    DNA
    TYPE functioning gene
    STRUCTURE 4.59 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1585 11.21 107 - 2013 24231807
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • is essential for uniporter current and additionally bridges the calcium-sensing role of MICU1 and MICU2 with the calcium-conducting role of MCU
  • its known MCU-activating function is mediated by the interaction of transmembrane helices from both proteins
  • identified as a uniporter subunit absolutely required for Ca2+ permeation
  • its second function is to maintain tight MICU1, MICU2 regulation of the MCU pore, a role that requires SMDT1 to bind MICU1 using its conserved C-terminal polyaspartate tail
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • was required for the interaction of MCU with MICU1 and MICU2
  • MICU1 is a key regulator of the mitochondrial Ca(2+) uniporter (MCU) that together with the essential MCU regulator (SMDT1) forms the mitochondrial Ca(2+) channel
  • MCU channel activity is governed by matrix Ca(2+) concentration through SMDT1
  • SMDT1-dependent regulation of MCU channel activity requires intermembrane space-localized MICU1, MICU2, and cytoplasmic Ca(2+)
  • MCUR1 binds to MCU and SMDT1 and function as a scaffold factor
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS