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FLASH GENE
Symbol ZGLP1 contributors: mct/npt - updated : 15-09-2020
HGNC name zinc finger, GATA-like protein 1
HGNC id 37245
Location 19p13.2      Physical location : 10.415.479 - 10.420.233
Synonym name GATA like protein-1
Synonym symbol(s) GLP1, FLJ39511, FLJ39703, GLP-1, GATAD3, FLJ39703
DNA
TYPE functioning gene
STRUCTURE 4.75 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1997 - 271 - Li (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Endocrinepancreas    
Reproductivefemale systemovary    Homo sapiensFetal
 male systemtestis    Homo sapiensFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegranulosa cell Homo sapiensFetal
ReproductiveLeydig cell Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text high levels in the somatic cells of the developing gonads, including Leydig cells in the testes and granulosa cells in the ovaries
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • acting as a transcriptional repressor of GATA factor function
  • critical nuclear repressor in somatic cells of the gonad that is required for germ cell development
  • critical nuclear repressor in somatic cells of the gonad that is required for germ cell development, suggesting the importance of somatic-germ cell interactions in the regulation of this critical process
  • somatic cell protein ZGLP1 is not necessary for many pregranulosa cell functions but is required for germ cell survival
  • ZGLP1 is a regulator of adipogenesis, which could be an alternate pathway leading to improved lipid homeostasis and controlled downstream insulin signaling
  • acts downstream of bone morphogenetic protein, but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in female mice, Glp-1 deficiency leads to the absence of oocytes at birth