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FLASH GENE
Symbol EXOC3L2 contributors: mct - updated : 04-04-2012
HGNC name exocyst complex component 3-like 2
HGNC id 30162
Location 19q13.32      Physical location : 45.715.878 - 45.737.469
Synonym name
  • HBV X-transactivated gene 7 protein
  • protein 7 transactivated by hepatitis B virus X antigen (HBxAg)
  • Synonym symbol(s) XTP7, FLJ36147, MGC16332
    DNA
    TYPE functioning gene
    STRUCTURE 21.59 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1719 45.7 409 - 2011 21566143
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   moderately
    Endocrinethyroid   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • endothelial cells in developing blood vessels express elevated levels of EXOC3L2
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a coiled coil domain
  • HOMOLOGY
    Homologene
    FAMILY
  • SEC6 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • its function is required for KDR activation and directional migration of endothelial cells in response to gradients of VEGFA
  • required for directional endothelial cell migration in response to a gradient of VEGFA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with components of the exocyst complex
  • physically interacts with EXOC4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS