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FLASH GENE
Symbol SH3RF3 contributors: mct - updated : 02-03-2011
HGNC name SH3 domain containing ring finger 3
HGNC id 24699
Location 2q13      Physical location : 109.745.996 - 110.262.207
Synonym name
  • SH3 multiple domains 4
  • Plenty of SH3s
  • Synonym symbol(s) FLJ00204, POSH2, SH3MD4
    DNA
    TYPE functioning gene
    STRUCTURE 319.94 kb     8 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5608 - 882 - Karkkainen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestiveliver   highly Homo sapiens
    Endocrinepancreas     Homo sapiens
    Lymphoid/Immunespleen     Homo sapiens
     thymus     Homo sapiens
    Nervousbrain   highly Homo sapiens
     spinal cord     Homo sapiens
    Respiratorylung     Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    Muscularstriatumskeletal   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved N-terminal extension with GTP-loaded Rac1 binding activity and acting as a partial CRIB domain
  • four SH3 domains as well as a RING domain
  • a functional RING domain, that transfers E3 ligase activity to this protein, with Cys3HisCys4 AAs that is also found in SH3RF1 and SH3RF2
  • HOMOLOGY
    intraspecies homolog to c-Jun N-terminal kinase scaffold protein POSH (SH3RF1)
    Homologene
    FAMILY
    CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • signalling protein, PAK2-binding adaptor protein
  • scaffold protein that enhances JNK activation and apoptosis
  • may regulate JNK activation and consequent apoptosis under conditions of increased expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with GTP-loaded Rac using only a partial CRIB domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS